Arthritogenicity of collagen type II is increased by chlorination

Arthritogenicity of Type II Collagen Relevance of Posttranslational Modifications

Hydroxyl Radical Modification of Collagen Type II Increases Its Arthritogenicity and Immunogenicity

BACKGROUND The oxidation of proteins by endogenously generated free radicals causes structural modifications in the molecules that lead to generation of neo-antigenic epitopes that have implications in various autoimmune disorders, including rheumatoid arthritis (RA). Collagen induced arthritis (CIA) in rodents (rats and mice) is an accepted experimental model for RA. METHODOLOGY/PRINCIPAL FI...

Suppression of type II collagen-induced arthritis by intragastric administration of soluble type II collagen.

Although oral administration of protein antigens may lead to specific immunologic unresponsiveness, this method of immunoregulation has not been applied to models of autoimmune disease. Type II collagen-induced arthritis is an animal model of polyarthritis induced in susceptible mice and rats by immunization with type II collagen, a major component of cartilage. Intragastric administration of s...

Collagen type II modification by hypochlorite.

Oxidation of proteins is a common phenomenon in the inflammatory process mediated by highly reactive agents such as hypochlorite (HOCl/OCl(-)) produced by activated neutrophils. For instance, in rheumatoid arthritis hypochlorite plays an important role in joint destruction. One of the major targets for HOCl/OCl(-) is collagen type II (CII) - the primary cartilage protein. In our study, HOCl/OCl...

Aging is associated with increased collagen type IV accumulation in

Background: Microvascular alterations contribute to the development of stroke and vascular dementia. The goal of this study was to evaluate age and hypertension related changes of the basal lamina in cerebral microvessels of individuals, who died from non-cerebral causes. Results: We examined 27 human brains: 11 young and 16 old patients. Old patients were divided into two subgroups, those with...